Vol. 23 No. 2 (2026)
Medic Nutricia : Jurnal Ilmu Kesehatan, ISSN : 3025-8855

Articles

SYSTEMATIC LITERATURE REVIEW: FORMULASI TABLET DENGAN KEMPA LANGSUNG DARI BAHAN ALAM

DOI: https://doi.org/10.2238/25j0bd91

Published 2026-06-26

  • Afriani
    • ,
  • Nabila Safitri
    • ,
  • Iyang Ragel
    • ,
  • Rega Pratama Fitri
    • ,
  • Zira Zulfi
    • ,
  • Chelsi Olivia

Afriani
Universitas Muhammadiyah Riau

Nabila Safitri
Universitas Muhammadiyah Riau

Iyang Ragel
Universitas Muhammadiyah Riau

Rega Pratama Fitri
Universitas Muhammadiyah Riau

Zira Zulfi
Universitas Muhammadiyah Riau

Chelsi Olivia
Universitas Muhammadiyah Riau

Abstract

Tablet merupakan salah satu bentuk sediaan farmasi yang paling banyak digunakan karena memiliki stabilitas yang baik, mudah diproduksi, serta memberikan ketepatan dosis yang tinggi. Dalam beberapa tahun terakhir, pemanfaatan bahan alam sebagai bahan aktif dalam formulasi tablet semakin berkembang seiring meningkatnya minat masyarakat terhadap produk herbal. Metode kempa langsung menjadi salah satu metode yang banyak digunakan dalam pembuatan tablet berbahan alam karena prosesnya sederhana, ekonomis, dan mampu mempertahankan stabilitas senyawa aktif yang sensitif terhadap panas maupun kelembapan. Penelitian ini bertujuan untuk mengkaji berbagai penelitian mengenai formulasi tablet berbahan alam yang dibuat menggunakan metode kempa langsung melalui pendekatan Systematic Literature Review (SLR). Artikel yang dianalisis berasal dari berbagai basis data ilmiah dan dipublikasikan pada periode 2020–2025. Sebanyak 30 artikel memenuhi kriteria inklusi dan dianalisis berdasarkan jenis bahan alam, metode ekstraksi, pelarut yang digunakan, kandungan senyawa aktif, serta karakteristik formulasi tablet. Hasil kajian menunjukkan bahwa seluruh penelitian menggunakan metode kempa langsung sebagai teknik pembuatan tablet. Pelarut yang paling banyak digunakan adalah etanol, sedangkan metode ekstraksi yang paling dominan adalah maserasi. Bahan alam yang digunakan sangat beragam, mulai dari daun, batang, akar, buah, biji, hingga ekstrak herbal campuran. Evaluasi tablet yang paling sering dilakukan meliputi keseragaman bobot, kekerasan, friabilitas, waktu hancur, dan uji disolusi. Kajian ini menunjukkan bahwa metode kempa langsung merupakan pendekatan yang efektif dalam pengembangan tablet berbahan alam dengan mutu fisik yang memenuhi persyaratan farmasetika.

Keywords

tablet herbal, kempa langsung, bahan alam, formulasi tablet, systematic literature review.

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