FORMULASI DAN EVALUASI TABLET KUNYAH BERBASIS BAHAN ALAM: SEBUAH REVIEW ARTIKEL
Abstract
Chewable tablets are one of the oral pharmaceutical dosage forms developed to improve patient convenience and medication adherence, particularly among children, older adults, and individuals who experience difficulty swallowing conventional tablets. The utilization of natural materials as active ingredients in chewable tablet formulations has continued to expand due to their diverse bioactive compounds with potential pharmacological activities. This review article aimed to examine the development of the formulation and evaluation of naturalbased chewable tablets by analyzing 25 scientific articles published between 2021 and 2026. The study employed a literature review method by collecting and analyzing relevant articles from various scientific databases. The reviewed aspects included the types of natural materials, formulation methods, excipient composition, physical quality evaluation, and biological activities of the formulations. The findings indicated that wet granulation and direct compression were the most commonly used manufacturing methods. Excipients such as mannitol, microcrystalline cellulose (MCC), sorbitol, CMC-Na, gelatin, and carrageenan played important roles in producing chewable tablets with satisfactory physical quality. Furthermore, most natural materials contained bioactive compounds, including flavonoids, phenolic compounds, alkaloids, terpenoids, tannins, saponins, essential oils, and β- carotene, which contributed to various pharmacological activities. Overall, natural-based chewable tablets demonstrate considerable potential for further development as effective, safe, practical, and patient-friendly pharmaceutical and nutraceutical dosage forms.Keywords
chewable tablets, evaluation, formulation, natural ingredients
References
- Andarifera, A. Z., Zaini, E., Yosmar, R., & Fitriani, L. (2025). Formulation and physical
- characterization of chewable gummy from galangal rhizome extract (Kaempferia galanga
- L.) as a nutraceutical product. Jurnal Sains Farmasi & Klinis, 12(2), 145–155.
- https://doi.org/10.25077/jsfk.12.2.145-155.2025
- Banik, B., Sharma, A., & Nasrin, A. (2021). Development and evaluation of carminative herbal
- chewable tablets based on turmeric, fennel seed, and mango ginger. Asian Pacific Journal
- of Health Sciences, 8(3), 141–145. https://doi.org/10.21276/apjhs.2021.8.3.24
- Development, F., et al. (2024). Formulation development and evaluation of riboflavin chewable
- tablet using Moringa oleifera gum powder for taste masking and better patient compliance.
- 11(1), 324–336.
- Gemilang, N. P., Jayani, N. I. E., & Rani, K. C. (2023). Formulation of chewable gummy tablet
- of Moringa oleifera L. leaf extract using combination kappa carrageenan and iota
- carrageenan. In Proceedings (Vol. 2022). Atlantis Press. https://doi.org/10.2991/978-94-
- 6463-322-1_21
- Ghurghure, S. M., Pathan, M. S. A., Surwase, P. R., Shirure, P. D., & Gote, P. M. (2023).
- Formulation and evaluation of chewable tablets containing aqueous extract of Zingiber
- officinale. World Journal of Pharmacy and Pharmaceutical Sciences, 8(3), 1416–1424.
- https://doi.org/10.20959/wjpps20193-13328
- Haque, A. F., Mulyani, E., Fauziah, D. W., & Joeis, J. (2023). Formulasi tablet kunyah dari
- minyak atsiri jeruk kalamansi (Citrofortunella microcarpa) dengan variasi pemanis sorbitol.
- SINTA Journal (Science, Technology, and Agricultural), 4(1), 51–58.
- https://doi.org/10.37638/sinta.4.1.51-58
- Huang, X., et al. (2025). Chewable tablets containing rape bee pollen and maca attenuate
- testosterone propionate-induced benign prostatic hyperplasia in Sprague–Dawley rats by
- regulating the gut microbiota and modulating the IL-6/JAK2/STAT3 signaling pathway.
- Frontiers in Microbiology, 16, 1–16. https://doi.org/10.3389/fmicb.2025.1547724
- Hurkadale, P. J., Channi, N. M., Bolmal, U. B., Bidikar, C. M., & Hj, P. (2023). Formulation
- design and optimization of poly-herbal chewable tablets using JMP tool. 2, 1–11.
- https://doi.org/10.35702/Pharmacogn.10003
- Karaoğlu, Ö., et al. (2023). Chewable tablet with herbal extracts and propolis arrests Wuhan
- and Omicron variants of SARS-CoV-2 virus. Journal of Functional Foods, 105.
- https://doi.org/10.1016/j.jff.2023.105544
- Karthick, S., Vasanthan, A., & Senthilkumar, K. L. (2024). Formulation and evaluation of
- chewable tablet of Solanum nigrum L. leaf extract. 2(4), 1265–1280.
- https://doi.org/10.5281/zenodo.11092173
- Khairnar, M., Desale, D., Kale, S., Deore, H., Bhadane, D., & Shaikh, S. (n.d.). Formulation and
- evaluation of chewable tablets of Catharanthus roseus leaf. 2(4), 22–31.
- Khairnar, U., Chole, R., Hire, R., & Bharti, G. (2025). Development of a novel herbal chewable
- tablet for dental caries treatment. International Journal of Scientific Research and
- Technology, 2(1), 423–431.
- Lestari, U., Novra, A., & Kurniadi, R. (2025). Chewable tablet formulation from ethanol extracts of betel, areca, and gambir as a substitute for betel. Jurnal Jamu Indonesia, 10(1), 49–54.
- https://doi.org/10.29244/jji.v10i1.311
- Mankar, S. D., Musale, P., Bhawar, S. B., Siddheshwar, S. S., & Dighe, S. B. (2024). Exploring
- the synergistic effect in polyherbal chewable antacid tablets: Formulation and evaluation
- study. Current Issues in Pharmacy and Medical Sciences, 37(3), 153–161.
- https://doi.org/10.2478/cipms-2024-0025
- Matulyte, I., Mataraite, A., Velziene, S., & Bernatoniene, J. (2021). The effect of Myristica
- fragrans on texture properties and shelf-life of innovative chewable gel tablets.
- Pharmaceutics, 13(2), 1–15. https://doi.org/10.3390/pharmaceutics13020238
- P. Gigi. (2026). Formulasi dan uji efektivitas tablet kunyah ekstrak kulit kayu manis
- (Cinnamomum burmannii) sebagai inovasi sediaan. 3, 7–8.
- Patil, J., Vishwajith, V., & Gopal, V. (2021). Formulation development and evaluation of
- chewable tablets containing non-sedating antihistamine. Journal of Pharmaceutical and
- Scientific Innovation, 1(3), 112–117.
- Pratama, N. P., Purnomo Sari, K. R., & Kurniawati, E. (2022). Formulation of chewable tablet
- preparations from the combination of Azadirachta indica A. Juss. and Gynura procumbens
- (Merr.). Jurnal Farmasi Sains dan Praktis, 8(1), 124–133.
- https://doi.org/10.31603/pharmacy.v8i1.5918
- Putthong, C., Panmanee, T., Charoensit, P., Ross, S., Tongpoolsomjit, K., & Viyoch, J. (2025).
- Efficacy of natural β-carotene chewable tablets derived from banana (Musa AA) pulp in
- reducing UV-induced skin erythema. Nutrients, 17(1), 1–13.
- https://doi.org/10.3390/nu17010065
- Rani, K. C., Jayani, N. I. E., Setaratika, M., & Dewi, S. M. K. (2023). Optimization of sucrose
- and propylene glycol concentration in the formulation of chewable gummy tablets of
- Moringa oleifera leaf extract. BIOEDUSCIENCE, 7(1), 73–87.
- https://doi.org/10.22263/j.bes/7110751
- Rustiani, E., Widayanti, K., & Zaddana, C. (2022). IX(1), 63–70.
- Rustiani, E., Zulkarnaen, D. M. Z., & Andini, S. (2024). Formulasi tablet kunyah kombinasi
- tepung cangkang telur dan ekstrak daun kelor (Moringa oleifera L.). Majalah Farmasetika,
- 9(7), 83–96. https://doi.org/10.24198/mfarmasetika.v9i7.58884
- Sawant, A., Ghube, S., Parab, V., Sawant, A., & Rawool, G. (2026). Formulation and evaluation
- of Tanacetum parthenium chewable tablets for anti-migraine activity. 4(3), 3334–3347.
- https://doi.org/10.5281/zenodo.19230545
- Utami, A. S., Nawangsari, D., & Setianingsih, S. (2024). Effect of CMC-Na concentration as a
- binder in the formulation of chewable tablets of ethanol extract of onion tubers (Allium
- cepa L.). Health and Biological Science ICHBS, 247–264.
- Verkhovod, V. M., & Kovalevska, I. V. (2026). The development of a tablet formulation of
- quercetin with carrot extract with improved solubility for the prevention of
- atherosclerosis. 111, 36–4