Vol. 23 No. 3 (2026)
Medic Nutricia : Jurnal Ilmu Kesehatan, ISSN : 3025-8855

Articles

PERKEMBANGAN FORMULASI DAN KARAKTERISASI CANGKANG KAPSUL BERBASIS BAHAN ALAM SEBAGAI ALTERNATIF GELATIN

DOI: https://doi.org/10.2238/z49x7k24

Published 2026-07-12

  • Putri Tri Hartini
    • ,
  • Joyce Victory
    • ,
  • Devi Permata Sari
    • ,
  • Nadya Hafizah

Putri Tri Hartini
Universitas Muhammadiyah Riau

Joyce Victory
Universitas Muhammadiyah Riau

Devi Permata Sari
Universitas Muhammadiyah Riau

Nadya Hafizah
Universitas Muhammadiyah Riau

Abstract

This study aims to review the development of non-gelatin capsule shells based on natural polymers using a Systematic Literature Review (SLR) method. Various scientific studies were analyzed to evaluate the potential of carrageenan, alginate, starch, pectin, and cellulose as alternative materials to gelatin. The results show that each polymer exhibits different characteristics in film-forming ability, mechanical strength, and disintegration time. Carrageenan shows strong gelation properties, cellulose provides structural strength, while starch and alginate offer advantages in raw material availability. However, no single polymer fully meets the ideal requirements of capsule shells. Therefore, a composite polymer approach is considered the most effective strategy for developing stable, functional, and sustainable non-gelatin capsules.

Keywords

non-gelatin capsule, natural polymers, carrageenan, cellulose, SLR

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References

  1. Adi, I. K., Totou, R. R. A., Cahyani, M. D., & Puspasari, I. (2023). Plant-based capsule shell from pectin and glucomannan. Chemical Engineering Transactions, 106, 1309-1314. https://doi.org/10.3303/CET23106219
  2. Agustin, N., Lismeri, L., & Azwar, E. (2021). Effect of added pectin and microcrystalline cellulose (MCC) on capsule shell quality. https://doi.org/10.23960/jesr.v3i2.64
  3. Ahmadpour, F., Zolfaghari, M. A., & Jafari, D. (2024). Design and preparation of a novel pullulan hard capsule formulation: A promising green candidate. Heliyon, 10(9), e28969. https://doi.org/10.1016/j.heliyon.2024.e28969
  4. El Viera, B. V., Saepudin, S., & Saidah, L. I. A. (2026). Preparation and evaluation of capsule shell films formulated from brown seaweed alginate (Sargassum crassifolium). Jurnal Pengabdian Magister Pendidikan IPA, 21(1). https://doi.org/10.29303/jpm.v21i1.10824
  5. Erawati, E., Hamid, H., Musthofa, M., Fatoni, R., Nurwaini, S., Rahmah, A. U., & Setiawan, P. R. (2023). Drug release kinetics of capsule shells from seaweed carrageenan extract (Eucheuma cottonii) and potato starch as a gelling agent. Bulletin of the National Research Centre, 47, Article 145. https://doi.org/10.1186/s42269-023-01045-6
  6. Fatonah, I. S., Kadarusman, S. F., Nurulaeni, S. Q., Delilah, G. G. A., & Setiadji, S. (2024). Studi awal pembuatan cangkang kapsul dari komposit pati garut (Maranta arundinacea) dan karagen. https://conferences.uinsgd.ac.id/index.php/gdcs/article/view/2352
  7. Hartini, Y. S., Kristanto, A. M. R., & Wahyuningrum, T. E. (2025). Structural and functional enhancement of halal gelatin capsules reinforced with corn husk cellulose. Polymers, 17(20), 2803. https://doi.org/10.3390/polym17202803
  8. Indriawan, K. A., Sa'adah, H., & Helmidanora, R. (2023). Formulasi kapsul antidiabetes ekstrak umbi bawang dayak (Eleutherine palmifolia (L.) Merr.) dengan variasi konsentrasi Avicel PH 101 dan pregelatinized starch. https://doi.org/10.33759/jrki.v5i3.402
  9. Jamwal, P., & Dhongade, H. J. (2024). Development, optimization, and characterization of plant-polymer hard capsules prepared from corn starch, agar-agar, sodium alginate, and HPMC. Journal of Population Therapeutics and Clinical Pharmacology, 31(8), 1125-1138. https://doi.org/10.53555/j7yvge16
  10. Khairunnisa, A., Viogenta, P., Kartinah, N., & Azzahra, D. A. (2025). The characterization of capsule shell from acid-hydrolyzed palm oil starch. Alchemy: Journal of Chemistry, 21(1), 72-81. https://doi.org/10.20961/alchemy.21.1.93550.72-81
  11. Mahardika, M., Dariyat, Susparini, N. T., & Amin, F. (2022). Sintesis dan karakterisasi cangkang kapsul non-gelatin dari lidah buaya (Aloe vera L.)-karagenan. https://doi.org/10.30653/medsains.v2i2.322
  12. Mahmoud, N., Belaabed, N. E. H., & Ghazouani, H. (2025). Synthesis and characterization of sodium carboxymethylcellulose from Sansevieria trifasciata as an alternative raw material for capsule shell. Turkish Journal of Pharmaceutical Sciences. https://doi.org/10.4274/tjps.galenos.2025.40070
  13. Mardiyah, U., Hartulistiyoso, E., & Iskandar, B. H. (2024). Characteristics of carrageenan from seaweed hydrolysis using marine fungi as hard-shell capsule material. Jurnal Pengolahan Hasil Perikanan Indonesia. https://doi.org/10.17844/jphpi.v27i8.51946
  14. Muhtadi, M., Suhendi, A., Haryoto, H., Indrayudha, P., Maulana, R., & Suranto, S. (2025). Innovative capsule shell formula: Glucomannan and carrageenan with natural butterfly pea flower (Clitoria ternatea) extract colorant. BIO Web of Conferences, 180, 01007. https://doi.org/10.1051/bioconf/202518001007
  15. Ni'mah, Y. L., Suprapto, S., Harmami, H., Ulfin, I., & Fauziyah, P. A. (2022). The fabrication of water-soluble chitosan capsule shell modified by alginate and gembili starch (Dioscorea esculenta L.). Journal of Renewable Materials, 10(9), 2621-2634.
  16. Pradaniz, E. P., Prawesti, W. A., Iwahyuningtyas, I., Naufiannida, N. A., Maharani, A., & Fadilah. (2025). Synthesis of gelatin-free halal capsule shells based on microcrystalline cellulose from solid sugar palm (Aren) waste. Equilibrium Journal of Chemical Engineering, 9(1).
  17. Rambe, F. Y., Setiawan, D. H., & Kusuma, S. A. F. (2024). Effect of corn starch and glycerol additions on the characteristics of capsule shells from seaweed carrageenan. Jurnal Farmasi dan Praktik Alami. https://journal.ugm.ac.id/v3/JFPA
  18. Rissa, M. M., Wijaya, A., & Urfiyya, Q. A. (2025). Formulasi dan evaluasi fisik sediaan kapsul ekstrak daun binahong (Anredera cordifolia Steen.) sebagai antidiabetes. https://doi.org/10.51771/fj.v5i1.1262
  19. Rizal, R., Nofrizal, N., & Bakri, L. P. (2025). Formulation and characterization of capsule shells from breadfruit peel (Artocarpus altilis (Park) Fosberg). Pharmaceutical Science and Technology, 9(1). https://doi.org/10.11648/j.pst.20250901.12
  20. Sabara, Z., Mutmainnah, A., Kalsum, U., Afiah, I. N., Husna, I., Saregar, A., Umam, R., & Irzaman. (2023). Sugarcane bagasse as the source of nanocrystalline cellulose for gelatin-free capsule shell. International Journal of Biomaterials, 2023, Article 8843274. https://doi.org/10.1155/2023/8843274
  21. Soraya, M., Putri, R. P. G., Purwoto, H., Royanti, I., Dyah, C. K., Sari, D. D. P., & Laksono, H. (2024). Enhancing carrageenan-based capsule shell formulation from Kappaphycus striatum for accelerated disintegration time with multiple disintegrant. IOP Conference Series: Earth and Environmental Science, 1377(1), 012003. https://doi.org/10.1088/1755-1315/1377/1/012003
  22. Suparman, A., Herawati, D., & Fitratul, Z. T. (2019). Karakterisasi dan formulasi cangkang kapsul dari tepung pektin kulit buah cokelat (Theobroma cacao L.). https://media.neliti.com/media/publications/458726-karakterisasi-dan-formulasi-cangkang-kap-d0a48337.pdf
  23. Zilhadia, Z., Harahap, Y., Jaswir, I., & Anwar, E. (2022). Evaluation and characterization of hard-shell capsules formulated by using goatskin gelatin. Polymers, 14(20), 4416. https://doi.org/10.3390/polym14204416
  24. Permata, S. D. (2022). Formulasi cangkang kapsul dari kombinasi karagenan dan pektin apel menggunakan pendekatan design of experiment (Skripsi, Universitas Sriwijaya). Repository Universitas Sriwijaya. https://repository.unsri.ac.id/80440/10/RAMA_48201_08061381823108_0028058601_0009107502_01_front_ref.pdf
  25. Amalina, N., Anggraeni, Y., & Dhilasari, E. M. (2020). Formulasi cangkang kapsul dengan kombinasi kappa karagenan dan iota karagenan. Jurnal Pengabdian Kepada Kesehatan, 1(1). https://ejournal.melekliterasi.com/index.php/JPKK/article/view/208/165

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