Vol. 23 No. 3 (2026)
Medic Nutricia : Jurnal Ilmu Kesehatan, ISSN : 3025-8855

Articles

PERBANDINGAN PENGARUH JENIS PENYALUTAN TERHADAP STABILITAS DAN PROFIL PELEPASAN OBAT PADA TABLET: ARTIKEL RIVIEW

DOI: https://doi.org/10.2238/54kw3s63

Published 2026-07-05

  • Marisa Kemala Rozi
    • ,
  • Eni Lutviana Fadila
    • ,
  • Bintang Auliya Tyananda
    • ,
  • Alfira Nur Adella
    • ,
  • Tita Ester
    • ,
  • Nur Hafizah
    • ,
  • Sintya Rindi Utami
    • ,
  • Lia Wildah Hasanah
    • ,
  • Alda Azzahra Fadila
    • ,
  • Putri Hermaisya Harahap
    • ,
  • Ryan Dwi Prayoga

Marisa Kemala Rozi
Universitas Muhammadiyah Riau

Eni Lutviana Fadila
Universitas Muhammadiyah Riau

Bintang Auliya Tyananda
Universitas Muhammadiyah Riau

Alfira Nur Adella
Universitas Muhammadiyah Riau

Tita Ester
Universitas Muhammadiyah Riau

Nur Hafizah
Universitas Muhammadiyah Riau

Sintya Rindi Utami
Universitas Muhammadiyah Riau

Lia Wildah Hasanah
Universitas Muhammadiyah Riau

Alda Azzahra Fadila
Universitas Muhammadiyah Riau

Putri Hermaisya Harahap
Universitas Muhammadiyah Riau

Ryan Dwi Prayoga
Universitas Muhammadiyah Riau

Abstract

Penyalutan tablet merupakan salah satu teknologi formulasi yang berperan penting dalam meningkatkan stabilitas sediaan serta mengendalikan profil pelepasan obat. Artikel review ini bertujuan untuk membandingkan pengaruh berbagai jenis penyalutan terhadap stabilitas dan profil pelepasan obat pada tablet berdasarkan hasil penelitian yang telah dipublikasikan. Metode yang digunakan adalah literature review dengan menganalisis 25 artikel ilmiah terbitan tahun 2020-2025 yang diperoleh dari Google Scholar, PubMed, ScienceDirect, SpringerLink, dan MDPI. Data dianalisis secara deskriptif dengan membandingkan jenis penyalut, tujuan penelitian, hasil uji stabilitas, dan profil pelepasan obat. Hasil kajian menunjukkan bahwa salut film efektif meningkatkan stabilitas fisik dan kimia tablet tanpa menghambat disolusi secara bermakna, sedangkan salut enterik mampu melindungi obat dari degradasi di lambung dan mengarahkan pelepasan di usus. Penyalut pelepasan termodifikasi memberikan pelepasan obat yang lebih terkendali dan mempertahankan kadar obat lebih lama. Dengan demikian, pemilihan jenis penyalut yang tepat sangat menentukan kualitas, stabilitas, bioavailabilitas, dan efektivitas terapi sediaan tablet sesuai dengan karakteristik bahan aktif dan tujuan penghantaran obat.

Keywords

tablet, penyalutan, salut film, salut enterik, stabilitas, profil pelepasan obat

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References

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