Vol. 23 No. 3 (2026)
Medic Nutricia : Jurnal Ilmu Kesehatan, ISSN : 3025-8855

Articles

PERKEMBANGAN FORMULASI TABLET DENGAN METODE KEMPA LANGSUNG (DIRECT COMPRESSION)

DOI: https://doi.org/10.2238/na7bd205

Published 2026-07-13

  • Putri Tri Hartini
    • ,
  • Joyce Victory
    • ,
  • Hania Safitri Ramadhani
    • ,
  • Shentya Putri Serayu

Putri Tri Hartini
Universitas Muhammadiyah Riau

Joyce Victory
Universitas Muhammadiyah Riau

Hania Safitri Ramadhani
Universitas Muhammadiyah Riau

Shentya Putri Serayu
Universitas Muhammadiyah Riau

Abstract

Tablets are one of the most widely used forms of pharmaceutical preparations because they have high dosage accuracy, good stability, easy to produce, and provide convenience in use. One of the tablet making methods that is widely applied is the direct compression method because the process is simpler, more efficient, and economical than the wet granulation method or dry granulation. This research aims to study the development of tablet formulation using the direct felt method based on the original research article (original research article) published in 2021–2026. The research was conducted using the literature review method. The article was obtained through searching the Google Scholar, PubMed, ScienceDirect, and ResearchGate databases using the keywords direct compression tablet, tablet formulation using direct compression, directly compressed tablet, immediate release tablet by direct compression, and direct compression method tablet. The article is then selected based on the inclusion and exclusion criteria so that 25 original research articles are obtained that meet the requirements. The results of the study show that the success of the tablet formulation is influenced by the characteristics of raw materials, the selection of excipients, and the control of process parameters. The use of excipients such as microcrystalline cellulose (MCC), lactose, crospovidone, croscarmellose sodium, and co-processed excipients has been proven to be able to increase the flow properties, compressibility, hardness of the tablet, and speed up the time to destroy the tablet. In addition, the application of the Quality by Design (QbD) approach, multivariate modeling, and continuous direct compression is able to increase process efficiency and produce more consistent tablet. Thus, the direct felt method is still an effective method and continues to develop in the development of modern tablet formulations.

Keywords

tablet, direct compression, formulation, excipient, pharmaceutical technology

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References

  1. Ahmed, M., Ali, S., & Khan, R. (2022). Direct compression tablets containing sitagliptin hydrochloride. Journal of Pharmaceutical Innovation, 17(4), 987–997. https://doi.org/10.1007/s12247-022-09600-x
  2. Hamman, J. H., Du Preez, J. L., & Botha, A. (2024). Applying the SeDeM expert diagram system for multiple component powder mixtures intended for direct compression. Pharmaceutics, 16(2), 278.
  3. Hartesi, B., Sutrisno, D., Chairani, S., & Ariska, P. (2022). Formulasi tablet asetosal menggunakan metode kempa langsung dengan bahan pengisi pati kentang pregelatinasi. Journal of Healthcare Technology and Medicine.
  4. Hartesi, B., Meirista, I., Mariska, R. P., Soyata, A., Fitria, & Lestari, O. (2023). Modifikasi pati beras ketan putih sebagai pengisi pada pembuatan tablet kempa langsung. Majalah Farmasetika, 8(1), 70–94.
  5. Hutabarat, R., & Tanuwijaya, A. (2024). Formulasi dan uji hedonik fast disintegrating tablet minyak atsiri Thymus vulgaris L. menggunakan metode kempa langsung. Indonesia Natural Research Pharmaceutical Journal.
  6. Indartantri, K. B., Noval, & Oktaviannoor, H. (2021). Formulasi dan evaluasi floating system tablet difenhidramin HCl menggunakan kombinasi matriks HPMC K4M dan Na CMC. Jurnal Surya Medika, 7(1).
  7. Kumar, R., Sharma, P., & Singh, V. (2023). Evaluation of direct compression properties of pharmaceutical powders. Journal of Drug Delivery Science and Technology, 84, 104580.
  8. Loke, Y. H., Chew, Y.-L., Janakiraman, A. K., Lee, S.-K., Uddin, A. B. M. H., Ng, H. S., Ming, L. C., & Liew, K. B. (2024). Development of a novel direct compressible co-processed excipient and its application for formulation of Mirtazapine orally disintegrating tablets. Drug Development and Industrial Pharmacy, 50(1), 36–44.
  9. Naik, R., Patel, D., & Shah, P. (2024). Enhancing paracetamol compressibility using the co-drying technique for direct compression. Pharmaceutics, 16(3), 361. https://doi.org/10.3390/pharmaceutics16030361
  10. Nasyafa, A., Putri, D., & Rahman, M. (2024). Formulasi dan evaluasi sediaan tablet dengan metode kempa langsung. Jurnal Ilmiah Farmasi Indonesia, 12(2), 98–107.
  11. Nurhayati, S., Lestari, A., & Wahyuni, D. (2025). Formulasi tablet hisap ekstrak elderberry menggunakan metode kempa langsung. Jurnal Farmasi Indonesia, 22(1), 44–53.
  12. Patel, N., Shah, M., & Desai, R. (2022). Quality by design approach for direct compression tablets. Pharmaceutical Development and Technology, 27(7), 812–821. https://doi.org/10.1080/10837450.2022.2094657
  13. Pauli, V., Kleinebudde, P., & Kuentz, M. (2022). A multivariate formulation and process development platform for direct compression. International Journal of Pharmaceutics, 625, 122071. https://doi.org/10.1016/j.ijpharm.2022.122071
  14. Pauli, V., Kleinebudde, P., & Kuentz, M. (2024a). Direct compression process optimization for tablet manufacturing. International Journal of Pharmaceutics, 661, 124592. https://doi.org/10.1016/j.ijpharm.2024.124592
  15. Pauli, V., Kleinebudde, P., & Kuentz, M. (2024b). Flexible modelling of the dissolution performance of directly compressed tablets. International Journal of Pharmaceutics, 657, 124296. https://doi.org/10.1016/j.ijpharm.2024.124296
  16. Prasetyo, B., Sari, N., & Hidayat, A. (2024). Optimasi formula tablet disintegrasi cepat natrium diklofenak menggunakan metode kempa langsung. Jurnal Sains Farmasi, 20(1), 31–40.
  17. Prastika, N., Putri, E., & Lestari, R. (2024). Formulation of orally disintegrating tablets of furosemide using crospovidone and croscarmellose sodium. Journal of Pharmaceutical Research International, 36(5), 14–24.
  18. Putri, D., Rahman, M., & Fitriani, S. (2021). Formulasi tablet parasetamol dengan eksipien co-processing untuk metode kempa langsung. Jurnal Farmasi Sains dan Terapan, 8(2), 65–73.
  19. Rahmawati, E., Sari, R., & Hidayat, F. (2024). Formulasi tablet parasetamol menggunakan pati biji durian sebagai bahan pengikat metode kempa langsung. Jurnal Farmasi Galenika, 10(1), 56–65.
  20. Sharma, P., Singh, R., & Verma, S. (2022). Formulation and evaluation of orodispersible tablets of aceclofenac by direct compression. Journal of Drug Delivery Science and Technology, 73, 103456. https://doi.org/10.1016/j.jddst.2022.103456
  21. Shiekmydeen, A., Ahmed, S., & Ibrahim, M. (2024). Optimization of immediate release tablets using PBPK modelling. Pharmaceutics, 16(4), 521. https://doi.org/10.3390/pharmaceutics16040521
  22. Stauffer, F., Reiser, M., & Kleinebudde, P. (2024). Batch vs continuous direct compression: A comparison of material processability and final tablet quality. International Journal of Pharmaceutics, 660, 124523. https://doi.org/10.1016/j.ijpharm.2024.124523
  23. Thoorens, G., Krier, F., & Evrard, B. (2022). Exploiting synergistic effects of brittle and plastic excipients in direct compression formulations. Pharmaceutics, 14(11), 2418. https://doi.org/10.3390/pharmaceutics14112418
  24. Veronica, A., Smith, J., & Brown, L. (2024). Functionality of wet-granulated disintegrant compared to directly incorporated disintegrant in tablet formulations. Pharmaceutics, 16(7), 945. https://doi.org/10.3390/pharmaceutics16070945
  25. Yusuf, M., Arifin, Z., & Siregar, D. (2023). Pembuatan dan karakterisasi tablet urea dengan metode kempa langsung. Jurnal Teknologi Farmasi Indonesia, 15(1), 22–30.

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