Vol. 23 No. 4 (2026)
Medic Nutricia : Jurnal Ilmu Kesehatan, ISSN : 3025-8855

Articles

FORMULASI DAN EVALUASI SEDIAAN LIP BALM EKSTRAK NADES KULIT LIDAH BUAYA (ALOE VERA) SEBAGAI ANTIOKSIDAN

DOI: https://doi.cibangsa.org/DOI-2026-28

Published 2026-08-27

  • Khairul Ichsan Armanda
    • ,
  • Liandhajani
    • ,
  • Linawaty

Khairul Ichsan Armanda
Fakultas Farmasi, Program Studi Ilmu Farmasi, Universitas 17 Agustus 1945 Jakarta

Liandhajani
Fakultas Farmasi, Program Studi Ilmu Farmasi, Universitas 17 Agustus 1945 Jakarta

Linawaty
Fakultas Farmasi, Program Studi Ilmu Farmasi, Universitas 17 Agustus 1945 Jakarta

Abstract

Lidah buaya (Aloe vera) contains secondary metabolites, particularly flavonoids and phenolic compounds, which have potential antioxidant activity. Aloe vera rind, as a by-product of gel processing, is still underutilized and can be developed as an active ingredient in cosmetic preparations. This study aimed to formulate Aloe vera rind extract using Natural Deep Eutectic Solvent (NADES) into a lip balm preparation and evaluate its physical characteristics, stability, and antioxidant activity. An experimental laboratory method was used with four formulations: F0 without extract, F1 with 6% extract, F2 with 8% extract, and F3 with 10% extract. Evaluation included organoleptic properties, homogeneity, pH, spreadability, adhesion, physical stability using a cycling test, and antioxidant activity using the DPPH method. Phytochemical screening indicated the presence of alkaloids, flavonoids, tannins, saponins, and phenolic compounds. All formulations met the physical requirements, with pH values of 4.94–6.42, spreadability of 5.02–5.99 cm, and adhesion of 6.36–7.08 seconds. The cycling test showed that all formulations remained physically stable after three cycles. Antioxidant activity increased with increasing extract concentration, with IC₅₀ values of 257.68, 194.90, 148.96, and 87.55 ppm for F0, F1, F2, and F3, respectively. F3 demonstrated the strongest antioxidant activity among the formulations.

Keywords

Aloe vera, antioxidant, DPPH, lip balm, Natural Deep Eutectic Solvent (NADES)

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References

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