Trigonometri : Journal Matematika dan Ilmu Pengetahuan Alam

Articles

Vol. 8 No. 3 (2026): Trigonometri : Journal Matematika dan Ilmu Pengetahuan Alam, ISSN 3030-8496

Studi In Silico Senyawa Flavonoid dari Daun Kelor (Moringa oleifera) sebagai Inhibitor Dipeptidyl Peptidase-4 (DPP-4) pada Diabetes Melitus Tipe 2

DOI:
https://doi.org/10.2238/9bbwh297
Submitted
July 13, 2026
Published
2026-07-13

Abstract

Penelitian ini bertujuan untuk menganalisis potensi senyawa bioaktif daun kelor (Moringa oleifera) sebagai inhibitor protein Dipeptidyl Peptidase-4 (DPP-4) menggunakan pendekatan in silico. Analisis dilakukan menggunakan SwissADME, ProTox-3.0, dan molecular docking dengan PyRx terhadap protein DPP-4 (PDB ID: 1X70). Senyawa yang diuji meliputi ellagic acid, p-coumaric acid, rhamnetin, apigenin, dan salicylic acid dengan sitagliptin sebagai kontrol positif. Hasil penelitian menunjukkan bahwa seluruh senyawa memenuhi aturan Lipinski dan memiliki profil toksisitas yang relatif baik. Hasil molecular docking menunjukkan bahwa rhamnetin memiliki afinitas pengikatan terbaik di antara senyawa uji dengan nilai binding affinity sebesar −8,1 kcal/mol, mendekati sitagliptin (−8,6 kcal/mol). Hasil penelitian ini menunjukkan bahwa rhamnetin berpotensi menjadi kandidat inhibitor DPP-4 dan memerlukan validasi lebih lanjut melalui pengujian in vitro dan in vivo.

References

  1. Amin, S., & Makia, F. F. (2025). Pendekatan In Silico dalam Penemuan Senyawa Bioaktif Tanaman sebagai Kandidat Obat Antidiabetes. September.
  2. Banerjee, P., Joly, P., Jouneau, L., Jaszczyszyn, Y., Bourge, M., Affaticati, P., Levraud, J., Boudinot, P., & Joly, J. (2022). Molecular and Cellular Analysis of the Repair of Zebrafish Optic Tectum Meninges Following Laser Injury.
  3. Daina, A., Michielin, O., & Zoete, V. (2017). SwissADME : a free web tool to evaluate pharmacokinetics , drug- likeness and medicinal chemistry friendliness of small molecules. Nature Publishing Group, October 2016, 1–13. https://doi.org/10.1038/srep42717
  4. Drucker, D. J. (2023). The expanding incretin universe : from basic biology to clinical translation. 1765–1779.
  5. Gehris, J. S., Oyeyemi, A. L., Baishya, M. L., Roth, S. C., & Stoutenberg, M. (2023). The role of physical activity in the relationship between exposure to community violence and mental health : A systematic review. Preventive Medicine Reports, 36(November), 102509. https://doi.org/10.1016/j.pmedr.2023.102509
  6. Holm, L. (2022). Dali server : structural unification of protein families. 50(May), 210–215.
  7. Kamara, I. F., Kumar, A. M. V, Maruta, A., Fofanah, B. D., Njuguna, C. K., Shongwe, S., Moses, F., Tengbe, S. M., Kanu, J. S., Lakoh, S., Mansaray, A. H. D., Selvaraj, K., Khogali, M., & Zachariah, R. (2022). Antibiotic Use in Suspected and Confirmed COVID-19 Patients Admitted to Health Facilities in Sierra Leone in 2020 – 2021 : Practice Does Not Follow Policy.
  8. Kitchen, D. B., Decornez, H., Furr, J. R., & Bajorath, J. (2004). DOCKING AND SCORING IN VIRTUAL SCREENING FOR DRUG DISCOVERY : METHODS AND APPLICATIONS. 3(November). https://doi.org/10.1038/nrd1549
  9. Kusuma, M., & Agustin, B. H. (2023). CAN OTHER COMPREHENSIVE INCOME AFFECT DIVIDEND PAYMENTS IN INDONESIA ? 12(1), 124–154. https://doi.org/10.22373/share.v12i1.15513
  10. Lai, M., Rocca, V. La, Amato, R., Freer, G., Costa, M., Spezia, P. G., Quaranta, P., Lombardo, G., & Piomelli, D. (2021). Ablation of Acid Ceramidase Impairs Autophagy and Mitochondria Activity in Melanoma Cells.
  11. Leo, C. H., Foo, S. Y., Choon, J., Tan, W., Tan, U., Chua, C. K., & Ong, E. S. (2022). Green Extraction of Orange Peel Waste Reduces TNF α -Induced Vascular Inflammation and Endothelial Dysfunction.
  12. Mutma’innah, M. N., Maherawati, & Rahayuni, T. (2022). Perubahan nutrisi ikan asam pedas dalam retort pouch dengan variasi waktu sterilisasi Nutrition change of ikan asam pedas in retort pouch with variation of sterilization time. 9(2), 75–85.
  13. Nguyen, Q. D., Merrill, P. T., Clark, W. L., Banker, A. S., Fardeau, C., Franco, P., Lehoang, P., Ohno, S., Rathinam, S. R., Thurau, S., & Abraham, A. (2016). Intravitreal Sirolimus for Noninfectious Uveitis : A Phase III Sirolimus Study Assessing Double-masKed Uveitis TReAtment ( SAKURA ). Ophthalmology, 123(11), 2413–2423. https://doi.org/10.1016/j.ophtha.2016.07.029
  14. Otunola, G. A., & Afolayan, A. J. (2013). Evaluation of the polyphenolic contents and some antioxidant properties of aqueous extracts of Garlic , Ginger , Cayenne Pepper and their mixture. 70, 66–70. https://doi.org/10.5073/JABFQ.2013.086.010
  15. Rottura, M., Drago, S. F. A., Molonia, A., Irrera, N., Marino, S., Scoglio, R., Orlando, L., Fazio, M. G. De, Squadrito, F., Arcoraci, V., & Imbalzano, E. (2023). Biomedicine & Pharmacotherapy Prescriptive behavior of non-vitamin K oral anticoagulants in patients affected by atrial fibrillation in general practice. 165(June). https://doi.org/10.1016/j.biopha.2023.115020
  16. Roy, R., Jahan, I., Roy, J., & Anwarul, M. (2023). Acute and subchronic toxicity profile of methanol extract of leaves of Fimbristylis miliacea ( L .) Vahl. Toxicology Reports, 10(November 2022), 301–307. https://doi.org/10.1016/j.toxrep.2023.02.006
  17. Taibi, D., Scifo, L., Bruno, N., & Fulantelli, G. (2023). Social Media Literacy to Support a Conscious Use of Social Media in Adolescents and Improve Their Psychological Well-Being : A Pilot Study.
  18. Utomo, A. A., Rahmah, S., & Amalia, R. (2020). FAKTOR RISIKO DIABETES MELLITUS TIPE 2 : 01, 44–53.
  19. Wang, X. X. D., & Stephen, Y. L. (2021). Plant-derived lignans as potential antiviral agents : a systematic review. In Phytochemistry Reviews (Vol. 0). Springer Netherlands. https://doi.org/10.1007/s11101-021-09758-0
  20. Yang, C., Chen, E. A., & Zhang, Y. (2022). Protein – Ligand Docking in the Machine-Learning Era. 1–24.

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